Uterine Fibroids and Heart Disease: What's the Link? (2026)

Here’s a startling fact: nearly 20% of women in their childbearing years may have uterine fibroids, and these seemingly unrelated growths could be silently increasing their risk of heart disease. But here’s where it gets even more alarming—a groundbreaking study reveals that women with fibroids face an 81% higher risk of developing long-term heart disease compared to those without. This isn’t just about reproductive health anymore; it’s a wake-up call for women’s heart health.

Dr. Susanna Mitro, a scientist with the Kaiser Permanente Division of Research, emphasizes the significance of this finding: ‘This study underscores the need to explore heart disease risk factors unique to women. Understanding how fibroids and heart disease are connected could be key to long-term prevention.’

And this is the part most people miss: the risk isn’t evenly distributed. Researchers analyzed health data from 2000 to 2022, comparing over 450,000 women with fibroids to 2.25 million without, all averaging 41 years old. After a decade of monitoring, the results were eye-opening:

  • Women with fibroids had nearly twice the risk of heart disease compared to those without.
  • For women under 40, the risk skyrocketed to more than three times higher if they had fibroids.
  • Across all racial and ethnic groups, fibroids were linked to a higher risk of coronary artery, cerebrovascular, and peripheral artery diseases.

Julia DiTosto, the study’s lead author and a PhD candidate at the University of Pennsylvania, calls this ‘an extremely important yet historically understudied area of research.’ She suggests shared biological pathways—like smooth muscle proliferation, fibrosis, calcification, and inflammation—could explain the link between fibroids and heart disease. But here’s the controversial part: is it the fibroids causing the increased risk, or is there another underlying factor driving both?

Uterine fibroids are noncancerous growths in the uterus, often influenced by hormones and genetics. While 80% of women may develop them by 50, many remain symptom-free. However, for some, they can cause pelvic pain, frequent urination, and heavy menstrual bleeding. The study’s observational nature lacked details on fibroid size, number, and location, leaving room for future research to dig deeper.

Should you be worried if you have fibroids? Heart disease is the leading cause of death among women, so these findings are a call to action. Experts recommend discussing your fibroid and heart health risk factors with a healthcare provider, ideally during your annual well-woman visit. As Dr. Mitro notes, ‘Fibroids aren’t just an ob-gyn issue—they could impact broader health conditions.’

But here’s the question we’re left with: Could fibroids be a red flag for heart disease, especially in younger women? And if so, how should this change the way we approach women’s health screenings? Share your thoughts in the comments—this conversation is far from over.

Uterine Fibroids and Heart Disease: What's the Link? (2026)
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